Caloric Restriction And Lifespan

Caloric restriction and lifespan. Interventions that modify aging and longevity. Discovery of Calorie Restriction. Discovery of Calorie Restriction! Survival of Calorie Restricted Rats. CR in mouse. CR phenotype. CR variations in rodents that produce extended lifespans. CR in mouse. CR extends lifespan in every. Animal tested. Primate CR trials. Primate NIA experiment. Primate CR trials UW experiment. Why does caloric restriction extend lifespan? Relationship between reproduction and lifespan. How does caloric restriction extend lifespan? Important characteristics of. Calorie restricted animals. Insulin Receptor Down Regulation. Receptor Down Regulation. Lower Insulin Sensitivity. Hormone Levels. CR rats Vs Ad Lib Fed. Caloric restriction. Will it work in humans? Caloric restriction in humans. Studies of CR in humans. Meyer et al. Fontana et al. CR in humans and other animals.

Reading: Handbook of Aging, Ch 15 A&S300-002 Jim Lund.

Environmental manipulation. Caloric restriction. Also called dietary restriction. Genetic manipulations. Drugs.

Start CR at weaing. Small size, longer development time. Start CR in young adults. Start CR in adults. Generally, lifespan extension proportional to time on CR. Fast and ab libitum diet on alternate days. Different diet compositions work: Fats, proteins, or carbohydrates can be cut. Different levels of CR, 10% - 70%, all work, generally more CR gives longer lifespan extension.

Matches NIA primate study Yes Yes Yes Yes Yes.

Matches Rodent Data Yes Yes Yes Yes Yes(mouse)/No(rat).

Human studies (-) Body weight (-) Fat and lean mass (-) Fasting glucose/insulin (-) Triglycerides (-) Body temperature.